Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

• Main Authors: Giacomo Rossino (Author), Annamaria Marra (Author), Roberta Listro (Author), Marco Peviani (Author), Elena Poggio (Author), Daniela Curti (Author), Giorgia Pellavio (Author), Umberto Laforenza (Author), Giulio Dondio (Author), Dirk Schepmann (Author), Bernhard Wünsch (Author), Martina Bedeschi (Author), Noemi Marino (Author), Anna Tesei (Author), Hee-Jin Ha (Author), Young-Ho Kim (Author), Jihyae Ann (Author), Jeewoo Lee (Author), Pasquale Linciano (Author), Marcello Di Giacomo (Author), Daniela Rossi (Author), Simona Collina (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling pathways. It is a debilitating disorder that affects up to 10% of the world's population. Although opioid analgesics are effective in reducing pain, they present severe risks; so, there is a pressing need for non...