The T-type Ca2+ Channel Inhibitor Mibefradil Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

• Main Authors: Da Hye Hong (Author), Dongki Yang (Author), Il-Whan Choi (Author), Youn Kyoung Son (Author), Won-Kyo Jung (Author), Dae-Joong Kim (Author), Jin Han (Author), Sung Hun Na (Author), Won Sun Park (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effects of mibefradil, a T-type Ca2+ channel inhibitor, on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. Mibefradil reduced the Kv current amplitude in a dose-dependent manner, with an apparent Kd value...