hUCMSCs carrying exenatide prevent T1DM by improving intestinal microflora composition and islet tissue damage repair

• Main Authors: Wei Wang (Author), Yahao Wang (Author), Jingwei Chi (Author), Xiaojun Tan (Author), Jianxia Hu (Author), Xiaolong Ma (Author), Xiaofang Sun (Author), Kui Che (Author), Wenshan Lv (Author), Yangang Wang (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is a rich source of MSCs, and human umbilical cord mesenchymal stem cells...