Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling

• Main Authors: Merve Keles (Author), Steve Grein (Author), Natali Froese (Author), Dagmar Wirth (Author), Felix A. Trogisch (Author), Rhys Wardman (Author), Shruthi Hemanna (Author), Nina Weinzierl (Author), Philipp-Sebastian Koch (Author), Stefanie Uhlig (Author), Santosh Lomada (Author), Gesine M. Dittrich (Author), Malgorzata Szaroszyk (Author), Ricarda Haustein (Author), Jan Hegermann (Author), Abel Martin-Garrido (Author), Johann Bauersachs (Author), Derk Frank (Author), Norbert Frey (Author), Karen Bieback (Author), Julio Cordero (Author), Gergana Dobreva (Author), Thomas Wieland (Author), Joerg Heineke (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of patients and mice. Cardiac overexpression of Gadlor1 and Gadlor2 aggravat...