Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain

• Main Authors: Zhihua Yi (Author), Shuai Ouyang (Author), Congfa Zhou (Author), Lihui Xie (Author), Zhi Fang (Author), Huilong Yuan (Author), Jinpu Yang (Author), Lifang Zou (Author), Tianyu Jia (Author), Shanhong Zhao (Author), Lin Li (Author), Liran Shi (Author), Yun Gao (Author), Guilin Li (Author), Shuangmei Liu (Author), Hong Xu (Author), Changshui Xu (Author), Chunping Zhang (Author), Shangdong Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: In this study, we investigated whether andrographolide (Andro) can alleviate neuropathic pain induced by HIV gp120 plus ddC treatment and the mechanism of its action.Methods: The paw withdrawal threshold and the paw withdrawal latency were observed to assess pain behaviors in all groups of the...