STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis

• Những tác giả chính: Cheng-Rong Yu (Tác giả), Ivy M. Dambuza (Tác giả), Yong-Jun Lee (Tác giả), Gregory M. Frank (Tác giả), Charles E. Egwuagu (Tác giả)
• Định dạng: Sách
• Được phát hành: Hindawi Limited, 2013-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

STAT3 regulates CD4+ T cell survival and differentiation. However, its effects on CD8+ T cells are not well understood. Here, we show that in comparison to WT CD8+ T cells, STAT3-deficient CD8+ T cells exhibit a preactivated memory-like phenotype, produce more IL-2, proliferate faster, and are more...