Pharmacokinetics, safety and tolerability of valbenazine in Korean CYP2D6 normal and intermediate metabolizers

• Main Authors: Woo Kyung Chung (Author), Inyoung Hwang (Author), Byungwook Kim (Author), Jihyun Jung (Author), Kyung‐Sang Yu (Author), In‐Jin Jang (Author), Jaeseong Oh (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Valbenazine is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved for tardive dyskinesia treatment by the US Food and Drug Administration; its major active metabolite (NBI‐98782) is a 45‐fold more potent inhibitor of VMAT2 than the parent drug. This study aimed to eval...