Silencing RNA for MMPs May Be Utilized for Cardioprotection

• Main Authors: Marta Banaszkiewicz (Author), Anna Krzywonos-Zawadzka (Author), Agnieszka Olejnik (Author), Agnieszka Noszczyk-Nowak (Author), Iwona Bil-Lula (Author)
• Format: Book
• Published: Hindawi-Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemia/reperfusion (I/R) injury is accompanied by an increase of matrix metalloproteinase 2 (MMP-2) activity, which degrades heart contractile proteins. The aim of the study was to investigate the effect of MMP-2 small interfering RNA (MMP-2 siRNA) administration on I/R heart. Isolated rat hearts...