Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II-Design, Synthesis, and Evaluation

Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II-Design, Synthesis, and Evaluation

Kynurenic acid is a neuroprotective metabolite of tryptophan formed by kynurenine aminotransferase (KAT) catalyzed transformation of kynurenine. However, its high brain levels are associated with cognitive deficit and with the pathophysiology of schizophrenia. Although several classes of KAT inhibit...

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Main Authors: Michal Maryška (Author), Lucie Svobodová (Author), Wim Dehaen (Author), Martina Hrabinová (Author), Michaela Rumlová (Author), Ondřej Soukup (Author), Martin Kuchař (Author)
Format: Book
Published: MDPI AG, 2021-12-01T00:00:00Z.
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