IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance

• Main Authors: Murphy Rinki (Author), Ibáñez Lourdes (Author), Hattersley Andrew (Author), Tost Jörg (Author)
• Format: Book
• Published: BMC, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Insulin like growth factor 2 (<it>IGF2</it>) is an imprinted gene, which has an important role in fetal growth as established in mice models. IGF2 is downregulated through hypomethylation of a differentially methylated re...