Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells

• Main Authors: Huihui Xu (Author), Hongyan Zhao (Author), Cheng Lu (Author), Qi Qiu (Author), Gui Wang (Author), Jing Huang (Author), Minghui Guo (Author), Baosheng Guo (Author), Yong Tan (Author), Cheng Xiao (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide, a purified component of Tripterygiumwilfordii Hook F, has been shown to have immunosuppressive and anti-inflammatory properties in rheumatoid arthritis (RA). Although triptolide has demonstrated that it could suppress bone destruction in collagen-induced mice, its therapeutic mechanism r...