Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist

• Main Authors: Hélène Salvator (Author), Amparo Buenestado (Author), Marion Brollo (Author), Emmanuel Naline (Author), Tatiana Victoni (Author), Elisabeth Longchamp (Author), Hermann Tenor (Author), Stanislas Grassin-Delyle (Author), Philippe Devillier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Roflumilast is an option for treating patients with severe COPD and frequent exacerbations despite optimal therapy with inhaled drugs. The present study focused on whether the phosphodiesterase (PDE) 4 inhibitor roflumilast and its active metabolite roflumilast N-oxide affect the release...