Clonal lineage of high grade serous ovarian cancer in a patient with neurofibromatosis type 1

• Main Authors: Eric J. Norris (Author), Wendell D. Jones (Author), Marius D. Surleac (Author), Andrei J. Petrescu (Author), Darla Destephanis (Author), Qing Zhang (Author), Issam Hamadeh (Author), Jeffrey S. Kneisl (Author), Chad A. Livasy (Author), Ram N. Ganapathi (Author), David L. Tait (Author), Mahrukh K. Ganapathi (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene encoding neurofibromin, which negatively regulates Ras signaling. NF1 patients have an increased risk of developing early onset breast cancer, however, the association between NF1 and high grade serous ovarian cancer (HGSOC) is un...