Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells

• Principais autores: Ibrahim H. Polat (Autor), Míriam Tarrado-Castellarnau (Autor), Adrian Benito (Autor), Claudia Hernandez-Carro (Autor), Josep Centelles (Autor), Silvia Marin (Autor), Marta Cascante (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2021-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Nucleotide pools need to be constantly replenished in cancer cells to support cell proliferation. The synthesis of nucleotides requires glutamine and 5-phosphoribosyl-1-pyrophosphate produced from ribose-5-phosphate via the oxidative branch of the pentose phosphate pathway (ox-PPP). Both PPP and glu...