Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells

• Main Authors: Ibrahim H. Polat (Author), Míriam Tarrado-Castellarnau (Author), Adrian Benito (Author), Claudia Hernandez-Carro (Author), Josep Centelles (Author), Silvia Marin (Author), Marta Cascante (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-08-01T00:00:00Z.
• Fag: article
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Nucleotide pools need to be constantly replenished in cancer cells to support cell proliferation. The synthesis of nucleotides requires glutamine and 5-phosphoribosyl-1-pyrophosphate produced from ribose-5-phosphate via the oxidative branch of the pentose phosphate pathway (ox-PPP). Both PPP and glu...