Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells

• Egile Nagusiak: Ibrahim H. Polat (Egilea), Míriam Tarrado-Castellarnau (Egilea), Adrian Benito (Egilea), Claudia Hernandez-Carro (Egilea), Josep Centelles (Egilea), Silvia Marin (Egilea), Marta Cascante (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Nucleotide pools need to be constantly replenished in cancer cells to support cell proliferation. The synthesis of nucleotides requires glutamine and 5-phosphoribosyl-1-pyrophosphate produced from ribose-5-phosphate via the oxidative branch of the pentose phosphate pathway (ox-PPP). Both PPP and glu...