Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway

• Egile Nagusiak: Xueru Li (Egilea), Yu Leng (Egilea), Qingzhi Jiang (Egilea), Ziwen Wang (Egilea), Peng Luo (Egilea), Chi Zhang (Egilea), Long Chen (Egilea), Yawei Wang (Egilea), Huilan Wang (Egilea), Xiaofeng Yue (Egilea), Chongxing Shen (Egilea), Yuanlinhan Zhou (Egilea), Chunmeng Shi (Egilea), Lin Xie (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Metformin has effective therapeutic effects in anti-tumor and anti-fibrotic diseases. However, how the antifibrotic effect of metformin in the eye and how it is transferred are still unclear. Here, the eye drop of metformin treatment was studied in Sprague-Dawley (SD) rats of glaucoma filtrating sur...