SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

• Main Authors: João Antônio Chaves de Souza (Author), Andressa Vilas Boas Nogueira (Author), Pedro Paulo Chaves de Souza (Author), Yeon Jung Kim (Author), Caroline Silva Lobo (Author), Guilherme José Pimentel Lopes de Oliveira (Author), Joni Augusto Cirelli (Author), Gustavo Pompermaier Garlet (Author), Carlos Rossa (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the p...