Evaluation of Actinium-225 Labeled Minigastrin Analogue [²²⁵Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

• Автори: Yun Qin (Автор), Stefan Imobersteg (Автор), Alain Blanc (Автор), Stephan Frank (Автор), Roger Schibli (Автор), Martin P. Béhé (Автор), Michal Grzmil (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of radiolabeled minigastrin analogues for targeted radionuclide therapy, which aims to deliver cytotoxic radiation specifically to cancer cells. Alpha emitters (e.g., actinium-225) possess high potency i...