Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

• Үндсэн зохиолчид: Mélanie Campana (Зохиогч), Lara Bellini (Зохиогч), Claude Rouch (Зохиогч), Latif Rachdi (Зохиогч), Nicolas Coant (Зохиогч), Noémie Butin (Зохиогч), Cécile L. Bandet (Зохиогч), Erwann Philippe (Зохиогч), Kelly Meneyrol (Зохиогч), Nadim Kassis (Зохиогч), Julien Dairou (Зохиогч), Eric Hajduch (Зохиогч), Benoit Colsch (Зохиогч), Christophe Magnan (Зохиогч), Hervé Le Stunff (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2018-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objectives: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms remains incomplete. Here, we aimed to determine the role of de novo ceramide synthesis in hypothalamus on the ons...