Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

• Main Authors: Mélanie Campana (Author), Lara Bellini (Author), Claude Rouch (Author), Latif Rachdi (Author), Nicolas Coant (Author), Noémie Butin (Author), Cécile L. Bandet (Author), Erwann Philippe (Author), Kelly Meneyrol (Author), Nadim Kassis (Author), Julien Dairou (Author), Eric Hajduch (Author), Benoit Colsch (Author), Christophe Magnan (Author), Hervé Le Stunff (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms remains incomplete. Here, we aimed to determine the role of de novo ceramide synthesis in hypothalamus on the ons...