Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats
Objectives: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms remains incomplete. Here, we aimed to determine the role of de novo ceramide synthesis in hypothalamus on the ons...
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Үндсэн зохиолчид: | , , , , , , , , , , , , , , |
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Формат: | Ном |
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Elsevier,
2018-02-01T00:00:00Z.
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Connect to this object online.3rd Floor Main Library
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A1234.567 |
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Хуулбар 1 | Бэлэн |