Population pharmacokinetics of imetelstat, a first‐in‐class oligonucleotide telomerase inhibitor

• Main Authors: Mario González‐Sales (Author), Ashley L. Lennox (Author), Fei Huang (Author), Chandra Pamulapati (Author), Ying Wan (Author), Libo Sun (Author), Tymara Berry (Author), Melissa Kelly Behrs (Author), Faye Feller (Author), Peter N. Morcos (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Imetelstat is a novel, first‐in‐class, oligonucleotide telomerase inhibitor in development for the treatment of hematologic malignancies including lower‐risk myelodysplastic syndromes and myelofibrosis. A nonlinear mixed‐effects model was developed to characterize the population pharmacokin...