Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.

• Main Authors: Junichiro En (Author), Sho Kitamoto (Author), Akira Kawashima (Author), Suguru Yonezawa (Author), Yoshito Kishi (Author), Norihisa Ishii (Author), Masamichi Goto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we t...