Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we t...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Public Library of Science (PLoS),
2017-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer. |
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| Item Description: | 1935-2727 1935-2735 10.1371/journal.pntd.0005834 |