Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice

• المؤلفون الرئيسيون: Jawaher Abdullah Alamoudi (مؤلف), Thanaa A. El-Masry (مؤلف), Mohamed Nasr (مؤلف), Ismail T. Ibrahim (مؤلف), Hanaa A. Ibrahim (مؤلف), Hebatallah M. Saad (مؤلف), Maysa M. F. El-Nagar (مؤلف), Samar Zuhair Alshawwa (مؤلف), Amal Alrashidi (مؤلف), Enas I. El Zahaby (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Orlistat (ORL) is an effective irreversible inhibitor of the lipase enzyme, and it possesses anticancer effects and limited aqueous solubility. This study was designed to improve the aqueous solubility, oral absorption, and tissue distribution of ORL via the formulation of nanocrystals (...