Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice

• Main Authors: Jawaher Abdullah Alamoudi (Author), Thanaa A. El-Masry (Author), Mohamed Nasr (Author), Ismail T. Ibrahim (Author), Hanaa A. Ibrahim (Author), Hebatallah M. Saad (Author), Maysa M. F. El-Nagar (Author), Samar Zuhair Alshawwa (Author), Amal Alrashidi (Author), Enas I. El Zahaby (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Orlistat (ORL) is an effective irreversible inhibitor of the lipase enzyme, and it possesses anticancer effects and limited aqueous solubility. This study was designed to improve the aqueous solubility, oral absorption, and tissue distribution of ORL via the formulation of nanocrystals (...