Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis

• Main Authors: Silvia Scaricamazza (Author), Valentina Nesci (Author), Illari Salvatori (Author), Gianmarco Fenili (Author), Marco Rosina (Author), Michela Gloriani (Author), Maria Paola Paronetto (Author), Luca Madaro (Author), Alberto Ferri (Author), Cristiana Valle (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Fag: article
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Background:Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by the degeneration of motor neurons that leads to muscle wasting and atrophy. Epidemiological and experimental evidence suggests a causal relationship between ALS and physical activity (PA). However, the i...