RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

• Main Authors: Saki Shimizu (Author), Gene-Errol Ringpis (Author), Matthew D Marsden (Author), Ruth V Cortado (Author), Holly M Wilhalme (Author), David Elashoff (Author), Jerome A Zack (Author), Irvin S Y Chen (Author), Dong Sung An (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transplantation of hematopoietic stem/progenitor cells (HSPC) modified with a lentiviral vector bearing a potent nontoxic short hairpin RNA (sh1005) directed to the HIV coreceptor CCR5 is capable of continuously producing CCR5 downregulated CD4+ T lymphocytes. Here, we characterized HIV-1 resistance...