Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

• Main Authors: Mahmoud F. Abo-Ashour (Author), Hadia Almahli (Author), Alessandro Bonardia (Author), Amira Khalil (Author), Tarfah Al-Warhi (Author), Sara T. Al-Rashood (Author), Hatem A. Abdel-Aziz (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author), Wagdy M. Eldehna (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In searching for new molecular drug targets, Carbonic Anhydrases (CAs) have emerged as valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 homeostasis, metabolic pathways, and much more. So, it is becoming attractive for medicinal chemists to design novel inhi...