Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

• Main Authors: Marcus R. Götz (Author), Juan A. Collado (Author), Javier Fernández-Ruiz (Author), Bernd L. Fiebich (Author), Laura García-Toscano (Author), María Gómez-Cañas (Author), Oskar Koch (Author), Andreas Leha (Author), Eduardo Muñoz (Author), Carmen Navarrete (Author), Maria R. Pazos (Author), Ulrike Holzgrabe (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel cannabinoids: 2-hydroxyethyl cannabidiolate (2-HEC), 2-hydroxypentyl cannabidiolate (2-HPC), 2,3-dihydroxypropyl cannabidiolate (GCBD), cyc...