Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

• Main Authors: Takanori Kanazawa (Author), Takumi Kurano (Author), Hisako Ibaraki (Author), Yuuki Takashima (Author), Toyofumi Suzuki (Author), Yasuo Seta (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2019-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We previously reported that siRNA delivery to the brain is improved by the nose-to-brain delivery route and by conjugation with polyethylene glycol-polycaprolactone (PEG-PCL) polymer micelles and the cell-penetrating peptide, Tat (PEG-PCL-Tat). In this study, we evaluated the nose-to-brain delivery...