Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.

• Main Authors: Stylianos eKosmidis (Author), Fanis eMissirlis (Author), Jose A. Botella (Author), Stephan eSchneuwly (Author), Tracey A. Rouault (Author), Efthimios M. C. Skoulakis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Iron is required for organismal growth. Therefore, limiting iron availability may be a key part of the host's innate immune response to various pathogens, for example in Drosophila infected with Zygomycetes. One way the host can transiently reduce iron bioavailability is by ferritin overexpress...