The Protective Effects of <i>α</i>-Mangostin Attenuate Sodium Iodate-Induced Cytotoxicity and Oxidative Injury via Mediating SIRT-3 Inactivation via the PI3K/AKT/PGC-1<i>α</i> Pathway

• Main Authors: Chen-Ju Chuang (Author), Meilin Wang (Author), Jui-Hsuan Yeh (Author), Tzu-Chun Chen (Author), Shang-Chun Tsou (Author), Yi-Ju Lee (Author), Yuan-Yen Chang (Author), Hui-Wen Lin (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well known that age-related macular degeneration (AMD) is an irreversible neurodegenerative disease that can cause blindness in the elderly. Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is a part of the pathogenesis of AMD. In this study, we evaluated the protective ef...