Virulence difference of five type I dengue viruses and the intrinsic molecular mechanism.

• Main Authors: Chunling Zou (Author), Chenxiao Huang (Author), Jinyu Zhang (Author), Qihan Wu (Author), Xiaohua Ni (Author), Jiufeng Sun (Author), Jianfeng Dai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) is the most important vector-borne virus globally. The safe and effective vaccines are still under development and there are no antiviral drugs for DENV induced diseases. In this study, we obtained five DENV1 isolates (DENV1 A to E) from the outbreak of dengue fever in 2014 of Gu...