A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis

• Main Authors: Nika Zielinski (Author), Dragos Baiceanu (Author), Antonela Dragomir (Author), Jan Heyckendorf (Author), Elmira Ibraim (Author), Niklas Köhler (Author), Christoph Leschczyk (Author), Cristina Popa (Author), Andrea Rachow (Author), Jens Sachsenweger (Author), Patricia Carballo (Author), Dagmar Schaub (Author), Hajo Zeeb (Author), Begna Tulu (Author), Andrew DiNardo (Author), Christoph Lange (Author), Maja Reimann (Author)
• Format: Book
• Published: Case Western Reserve University, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation. Objective: We aimed to identify and validate a host RNA-based biomarker that can predict linezolid-associated neuropathy before multidrug-resistant/...