Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA

• Main Authors: Roberta Guagliardo (Author), Pieterjan Merckx (Author), Agata Zamborlin (Author), Lynn De Backer (Author), Mercedes Echaide (Author), Jesus Pérez-Gil (Author), Stefaan C. De Smedt (Author), Koen Raemdonck (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra- and intracellular barriers, requiring its enc...