Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA

• Autori principali: Roberta Guagliardo (Autore), Pieterjan Merckx (Autore), Agata Zamborlin (Autore), Lynn De Backer (Autore), Mercedes Echaide (Autore), Jesus Pérez-Gil (Autore), Stefaan C. De Smedt (Autore), Koen Raemdonck (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2019-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra- and intracellular barriers, requiring its enc...