A new and simple non-chromatographic method for isolation of drug/linker constructs: vc-MMAE evaluation

• Main Authors: Meghdad Abdollahpour-Alitappeh (Author), Mahdi Habibi-Anbouhi (Author), Saeed Balalaie (Author), Farhad Golmohammadi (Author), Majid Lotfinia (Author), Mohsen Abolhassani (Author)
• Formato: Livro
• Publicado em: Shahrekord University of Medical Sciences, 2017-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Introduction: Auristatin and its derivatives (synthetic analogues of dolastatin 10, an antineoplastic natural product), are highly potent antimitotic agents which have attracted considerable attention because of their cytotoxic activity when targeting tumor cells in the form of antibody-drug conjuga...