Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer

• 主要な著者: Wen Li (著者), Xinhao Peng (著者), Jinyi Lang (著者), Chuan Xu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Defects in DNA damage repair may cause genome instability and cancer development. The tumor suppressor gene p53 regulates cell cycle arrest to allow time for DNA repair. The oncoprotein mouse double minute 2 (MDM2) promotes cell survival, proliferation, invasion, and therapeutic resistance in many t...