Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

• Main Authors: Cristina Ruiz-Ruiz (Author), Nuria García-Magro (Author), Pilar Negredo (Author), Carlos Avendaño (Author), Anindya Bhattacharya (Author), Marc Ceusters (Author), Antonio G. García (Author)
• Format: Book
• Published: The Company of Biologists, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 receptor (P2RX7, hereafter referred to as P2X7R). The pr...