Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

• Автори: Cristina Ruiz-Ruiz (Автор), Nuria García-Magro (Автор), Pilar Negredo (Автор), Carlos Avendaño (Автор), Anindya Bhattacharya (Автор), Marc Ceusters (Автор), Antonio G. García (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2020-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 receptor (P2RX7, hereafter referred to as P2X7R). The pr...