From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin

• Main Authors: Daniëlle Copmans (Author), Sara Kildgaard (Author), Emma Roux (Author), Michèle Partoens (Author), Gert Steurs (Author), Xinhui Wang (Author), Wim M. De Borggraeve (Author), Camila V. Esguerra (Author), Alexander D. Crawford (Author), Thomas O. Larsen (Author), Peter A. M. de Witte (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure compounds, the 2,5-diketopiperazine halimide and i...