Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor

• Main Authors: Nils Goehringer (Author), Yayi Peng (Author), Bianca Nitzsche (Author), Hannah Biermann (Author), Rohan Pradhan (Author), Rainer Schobert (Author), Marco Herling (Author), Michael Höpfner (Author), Bernhard Biersack (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of new anticancer drugs is necessary in order deal with the disease and with the drawbacks of currently applied drugs. Epigenetic dysregulations are a central hallmark of cancerogenesis and histone deacetylases (HDACs) emerged as promising anticancer targets. HDAC inhibitors are prom...