Global characterization of modifications to the charge isomers of IgG antibody

• Main Authors: Xinling Cui (Author), Wei Mi (Author), Zhishang Hu (Author), Xiaoyu Li (Author), Bo Meng (Author), Xinyuan Zhao (Author), Xiaohong Qian (Author), Tao Zhu (Author), Wantao Ying (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Posttranslational modifications of antibody products affect their stability, charge distribution, and drug activity and are thus a critical quality attribute. The comprehensive mapping of antibody modifications and different charge isomers (CIs) is of utmost importance, but is challenging. We intend...