Global characterization of modifications to the charge isomers of IgG antibody

• প্রধান লেখক: Xinling Cui (লেখক), Wei Mi (লেখক), Zhishang Hu (লেখক), Xiaoyu Li (লেখক), Bo Meng (লেখক), Xinyuan Zhao (লেখক), Xiaohong Qian (লেখক), Tao Zhu (লেখক), Wantao Ying (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Posttranslational modifications of antibody products affect their stability, charge distribution, and drug activity and are thus a critical quality attribute. The comprehensive mapping of antibody modifications and different charge isomers (CIs) is of utmost importance, but is challenging. We intend...