Global characterization of modifications to the charge isomers of IgG antibody

• Glavni autori: Xinling Cui (Autor), Wei Mi (Autor), Zhishang Hu (Autor), Xiaoyu Li (Autor), Bo Meng (Autor), Xinyuan Zhao (Autor), Xiaohong Qian (Autor), Tao Zhu (Autor), Wantao Ying (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2022-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Posttranslational modifications of antibody products affect their stability, charge distribution, and drug activity and are thus a critical quality attribute. The comprehensive mapping of antibody modifications and different charge isomers (CIs) is of utmost importance, but is challenging. We intend...