Histamine H3 Receptor Signaling Regulates the NLRP3 Inflammasome Activation in C2C12 Myocyte During Myogenic Differentiation

• Main Authors: Yan Chen (Author), Yuan Ma (Author), Jin Jin Feng (Author), Yi He Wang (Author), Tian Fang Li (Author), Katariina Nurmi (Author), Kari K. Eklund (Author), Jian Guo Wen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NLRP3 inflammasome has been implicated in impaired post-injury muscle healing and in muscle atrophy. Histamine receptors play an important role in inflammation, but the role of histamine H3 receptor (H3R) in myocyte regeneration and in the regulation of NLRP3 inflammasome is not known. We studied th...