DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone

• Autori principali: Lei Ding (Autore), Joseph A. Buckwalter (Autore), James A. Martin (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2017-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective and Design. To investigate whether endogenous damage-associated molecular patterns (DAMPs) or alarmins originated from mitochondria or nucleus stimulates inflammatory response in articular chondrocytes to cause chondrolysis which leads to cartilage degradation featured in posttraumatic ost...