Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine.

• Main Authors: Jill B Brelsford (Author), Jordan L Plieskatt (Author), Anna Yakovleva (Author), Amar Jariwala (Author), Brian P Keegan (Author), Jin Peng (Author), Pengjun Xia (Author), Guangzhao Li (Author), Doreen Campbell (Author), Maria Victoria Periago (Author), Rodrigo Correa-Oliveira (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), David Diemert (Author), Jeffrey M Bethony (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD...