Development and Validation of [³H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs

• Main Authors: Hazem Ahmed (Author), Livio Gisler (Author), Nehal H. Elghazawy (Author), Claudia Keller (Author), Wolfgang Sippl (Author), Steven H. Liang (Author), Ahmed Haider (Author), Simon M. Ametamey (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GluN2B-enriched <i>N</i>-methyl-<span style="font-variant: small-caps;">D</span>-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer's disease. No clinically valid GluN1/2B therapeutic exists due...