Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH

• Main Authors: David Montefusco (Author), Maryam Jamil (Author), Melissa A. Maczis (Author), William Schroeder (Author), Moshe Levi (Author), Suman Ranjit (Author), Jeremy Allegood (Author), Dipankar Bandyopadhyay (Author), Reuben Retnam (Author), Sarah Spiegel (Author), L. Ashley Cowart (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism is unclear. We have previously shown that mice with global deletion of SphK...