Ultrasound-targeted sirolimus-loaded microbubbles improves acute rejection of heart transplantation in rats by inhibiting TGF-β1-Smad signaling pathway, promoting autophagy and reducing inflammation

Acute rejection (AR) remains a pivotal complication and leading cause of mortality within the first year following heart transplantation (HT). In this study, we assessed the impact of ultrasound-targeted microbubbles loaded with sirolimus (SIR-MBs) on AR in a rat HT model and delved into the underly...

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Main Authors: Haiwei Bao (Author), Lulu Dai (Author), Huiyang Wang (Author), Tianan Jiang (Author)
Format: Book
Published: Elsevier, 2024-12-01T00:00:00Z.
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