Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats

• Main Authors: Long Yang (Author), Peng Xie (Author), Jianjiang Wu (Author), Jin Yu (Author), Xin Li (Author), Haiping Ma (Author), Tian Yu (Author), Haiying Wang (Author), Jianrong Ye (Author), Jiang Wang (Author), Hong Zheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial autophagy is involved in myocardial protection of sevoflurane postconditioning (SPostC) and in diabetic state this protective effect is weakened due to impaired HIF-1 signaling pathway. Previous studies have proved that deferoxamine (DFO) could activate impaired HIF-1α in diabetic stat...