Engineering a switchable single‐chain TEV protease to control protein maturation in living neurons

• Main Authors: Pietro Renna (Author), Cristian Ripoli (Author), Onur Dagliyan (Author), Francesco Pastore (Author), Marco Rinaudo (Author), Agnese Re (Author), Fabiola Paciello (Author), Claudio Grassi (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Engineered proteases are promising tools to address physiological and pathophysiological questions as well as to develop new therapeutic approaches. Here we introduce a new genetically encoded engineered single‐chain tobacco etch virus protease, allowing to control proprotein cleavage in di...