Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

• Главные авторы: Alejandro Carazo (Автор), Jan Dusek (Автор), Ondrej Holas (Автор), Josef Skoda (Автор), Lucie Hyrsova (Автор), Tomas Smutny (Автор), Tomas Soukup (Автор), Martin Dosedel (Автор), Petr Pávek (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Предметы: article
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The constitutive androstane receptor (CAR) is a nuclear receptor involved mainly in xenobiotic and endobiotic metabolism regulation. CAR is activated directly by its ligands via the ligand binding domain (LBD) or indirectly by inhibition of the epidermal growth factor (EGF) signaling. We found that...