The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial

• Main Authors: Ronit Shiri-Sverdlov (Author), Inês Magro dos Reis (Author), Yvonne Oligschlaeger (Author), Tim Hendrikx (Author), Dennis M. Meesters (Author), Annick Vanclooster (Author), Nele Vanhoutvin (Author), Ger H. Koek (Author), Marit Westerterp (Author), Christoph J. Binder (Author), David Cassiman (Author), Tom Houben (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a mediator between lipid metabolism dysfunction, oxidative stress and inflammation, oxidized low-density lipoprotein (oxLDL) is a promising therapeutical target in a wide range of metabolic diseases. In mice, pneumococcal immunization increases anti-phosphorylcholine and oxLDL antibody levels, an...